Method of treating cancer cells using CaMoO4/CaSiO3/g-C3N4 crystalline nanocomposite material
AssigneeImam Mohammad Ibn Saud Islamic University
InventorsMohamed Khairy Abdel Fattah Omran, Babiker Yagoub Elhadi Abdulkhair
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Abstract
A method of treating cancer cells includes incubating the cancer cells with a particulate crystalline nanocomposite and killing at least 60% of the cancer cells. The particulate crystalline nanocomposite includes a tetragonal CaMoO4 crystalline phase, a CaSiO3 crystalline phase, and a graphitic-C3N4 crystalline phase, where at least a fraction of the graphitic-C3N4 is in the form of mesoporous nanosheets.
Claims17
A method of treating cancer cells, comprising:
- incubating a plurality of cancer cells with a particulate crystalline nanocomposite, in an amount sufficient to induce apoptosis or kill at least 60% of the cancer cells, wherein the particulate crystalline nanocomposite comprises:
- a tetragonal CaMoO4 crystalline phase;
- a CaSiO3 crystalline phase;
- and
- a graphitic-C3N4 crystalline phase, wherein at least a portion of the graphitic-C3N4 is in the form of mesoporous nanosheets,
- wherein the cancer cells are breast cancer cells or liver cancer cells,
- wherein a ratio by weight of CaMoO4 to CaSiO3 to graphitic-C3N4 in the particulate crystalline nanocomposite is about (0.8-1.2):(0.8-1.2):(0.8-1.2),
- wherein at least a portion of the CaMoO4 and at least a portion of the CaSiO3 of the particulate crystalline nanocomposite are in the form of substantially spherical particles, and
- wherein the substantially spherical particles have an average particle size of about 5 to about 20 nm,
- wherein the particulate crystalline nanocomposite has a monomodal pore size distribution, as determined by Barrett-Joyner-Halenda (BJH) desorption analysis,
- wherein the particulate crystalline nanocomposite has an average pore diameter of from about 15 to about 25 nm, as determined by BJH desorption analysis, and
- wherein the particulate crystalline nanocomposite has a Brunauer-Emmett-Teller (BET) surface area of from about 60 to about 100 m2/g.
A pharmaceutical composition comprising at least one pharmaceutically acceptable excipient and a particulate crystalline nanocomposite comprising:
- a tetragonal CaMoO4 crystalline phase;
- a CaSiO3 crystalline phase;
- and
- a graphitic-C3N4 crystalline phase having at least a portion in the form of mesoporous nanosheets.
Dependencies are inferred from the claim text.