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US 12,648,907 B2Granted
Membrane protein scaffolds for exosome engineering
AssigneeLonza Sales AG
InventorsKevin P. Dooley, Douglas E. Williams, James E. Thornton
Life of this patent
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Abstract
The present disclosure relates to heterologous exosomal vesicle proteins (HEVPs), engineered exosomes comprising HEVPs, and methods of preparing and using these compositions, including therapeutic applications.
Claims14
An extracellular vesicle (EV) comprising a heterologous CD13 protein, wherein the EV is produced from a producer cell which does not naturally express the CD13 protein, and wherein the EV further comprises a prostaglandin F2 receptor negative regulator (PTGFRN) protein.
Dependencies are inferred from the claim text.