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US 12,648,892 B2Granted
Emergency eye wash
AssigneeLebrun Labs LLC
InventorsStewart Lebrun, Linda Nguyen
Life of this patent
Estimating the term…
Abstract
Immediate (e.g., within 10 minutes) high volume (e.g., more than 10 mls, 100-1000 mls preferred) washing of the eye for 1-15 minutes or more with a low concentration (e.g., 5-17 mM) of a freshly made ascorbate solution with a pH between 6 and 6.99 after chemical exposure, for example after accidental or malicious splash or spray, results in significantly reduced eye damage. Products, devices and methods are provided.
Claims8
A shelf-stable device or product for reducing extent and depth of keratocyte injury in a stroma of a cornea of a mammal, which cornea has been exposed to a strong oxidizing and/or corrosive chemical,
- the device or product producing a buffered eye wash solution of 0.2% ascorbic acid buffered to a pH of 6.99±0.5 and in an amount of 100 mL to 500 mL, comprising a two-part formulation having
- (a) a 100 mL to 500 mL liquid portion in at least a first compartment, and
- (b) a solid portion, wherein the first compartment holds a the liquid portion comprising a predefined amount of water or aqueous solution, and wherein the solid portion consists of an amount of powder within a premeasured range which results in solution of 0.2% ascorbic acid when added to the 100 mL to 500 mL liquid portion;
- and
- wherein separate storage in the device or product of the solid portion consisting of an amount of powder and of the liquid portion comprising a predefined amount of water or aqueous solution in the first compartment results, when the solid portion and liquid portion are combined and used as an eyewash solution within 10 minutes or less from exposure, in an increase in keratocyte survival and reduction in depth of corneal injury over stabilized ascorbate storage or over 10% ascorbic acid solution, and wherein the liquid portion of the first compartment mixed with the solid portion makes the 100 mL to 500 mL of a eyewash of 0.2% ascorbic acid solution, also contains a pH buffer, effecting a pH of 6.99±0.5 in the eyewash;
- and a nozzle, valve, spray, squeeze or handheld inversion nozzle for delivery to an eye or both eyes of a user subject the eyewash 0.2% ascorbic acid solution,
- wherein the nozzle, valve, spray, squeeze or handheld inversion nozzle allows application of a laminar flow across the eye or both eyes of the user subject when the eye or eyes are positioned within a predetermined range of distance from the nozzle, valve, spray, squeeze or handheld inversion nozzle, so as to wash the eye or eyes or wherein the device comprises an inverted eye gasket that permits incubation and/or bathing the eye or eyes of the user subject in a flow or a pool of the 100 mL to 500 mL eyewash 0.2% ascorbic acid solution by holding the device or product over the eye or eyes to form a seal around an eye socket with the eye gasket and raising the first compartment up so that the eyewash 0.2% ascorbic acid solution contacts the cornea of the eye or eyes, so as to wash the eye or eyes.
4 more elements
A device or product for reducing extent and depth of keratocyte injury in a stroma of a cornea of a mammal, which cornea has been exposed to a strong oxidizing and/or corrosive chemical,
- the drive or product producing a buffered eye wash solution of 0.1% to 0.3% ascorbic acid buffered to a pH of 6.0 to 6.99±0.5 and in an amount of 100 mL to 1000 mL comprising a two-part formulation having
- at least a first compartment and a solid portion consisting of an amount of powder,
- wherein the first compartment holds a liquid portion comprising a predefined amount of water or aqueous solution, and wherein the solid portion consists of an amount of powder within a premeasured range, and wherein the liquid portion mixes, or is capable of being mixed, with the solid portion so as to make the 100 mL to 1000 mL of a eyewash solution of 0.1% to 0.3% ascorbic acid,
- and wherein the eyewash solution also contains a pH buffer, effecting a pH of 6.0 to 6.99±0.5 in the eyewash solution of 0.1% to 0.3% ascorbic acid, and when used as an eyewash solution within 10 minutes or less from exposure, in an increase in keratocyte survival and reduction in depth of corneal injury over stabilized ascorbate storage or over 10% ascorbic acid solution,
- and a nozzle, valve, spray, squeeze or handheld inversion nozzle for delivery to an eye or both eyes of a user subject the eyewash 0.1% to 0.3% ascorbic acid solution;
- wherein the nozzle, valve, spray, squeeze or handheld inversion nozzle allows application of a laminar flow across the eye or both eyes of the user subject when the eye or eyes are positioned within a predetermined range of distance from the nozzle, valve, spray, squeeze or handheld inversion nozzle and so as to wash the eye or eyes or wherein the device comprises an inverted eye gasket that permits incubation and/or bathing the eye or eyes of the user subject in a flow or a pool of the eyewash solution of 0.1% to 0.3% ascorbic acid by holding the device or product over the eye or eyes to form a seal around an eye socket with the eye gasket and raising the first compartment up so that the eyewash solution of 0.1% to 0.3% ascorbic acid contacts the cornea of the eye or eyes.
3 more elements
Dependencies are inferred from the claim text.