Systems and methods for optogenetic imaging
AssigneeBruker Nano, Inc.
InventorsMark O. Trulson, Alice Stamatakis, Koen Visscher
Life of this patent
Estimating the term…
Abstract
Systems and methods configured for simultaneous imaging and stimulation using a microscope system. The microscope system can have a relatively small size compared to an average microscope system. The microscope can comprise in part an imaging light source and a stimulation light source. Light from the imaging light source and the stimulation light source can be spectrally separated to reduce cross talk between the stimulation light and the imaging light.
Claims24
A microscope system configured to simultaneously image and stimulate internal tissue within a biological subject, the microscope system comprising:
- an optical assembly that includes:
- an illumination optical arm of the microscope system comprising one or more illumination light-emitting elements and configured to direct imaging light to said internal tissue within a specified field-of-view (FOV);
- and
- a stimulation optical arm of the microscope system comprising one or more stimulation light-emitting elements and configured to direct stimulation light to said internal tissue within the specified FOV;
- and
- a housing dimensioned to house the optical assembly, the housing having a biocompatible outer surface;
- wherein said optical assembly is configured to generate images of said internal tissue over the volume defined by the FOV of at least 1 mm-by-1 mm and a depth of field of at least 300 microns without loss of spatial resolution and to be at least partially implanted within said biological subject in operation of the microscope system.
Dependencies are inferred from the claim text.