Device and method to determine the mean/average control of asthma/COPD over time and compliance to treatment
AssigneeVenkata Attili
InventorsVenkata Satya Suresh Attili, Anuradha Vutukuri
Life of this patent
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Abstract
A method to assess the disease status, determine the mean/average control of the disease and monitor the compliance to treatment over a period of time of a respiratory disease, comprising of predicting the degree of airway inflammation and disease activity by measuring the inflammatory markers, evaluating the mucosal integrity/damage by measuring the moisture levels of the exhaled air, evaluating the breathing function and obstruction by measuring the FEV1 value, and evaluating the symptom control by determining the COPD Score.
Claims9
A method implemented using a computational system to predict a disease status, determine a mean/average control of disease or monitor a compliance to treatment over a period of time of respiratory diseases, the method comprising:
- a. obtaining and analyzing measurements of multiple inflammatory markers, including fractional exhaled nitric oxide (FeNO), hydrogen peroxide (H2O2), pH, volatile organic compounds (VOCs), and carbon monoxide (CO), wherein the analyzing is performed by an inbuilt software program of a device configured to dynamically adjust a contribution weight of each of the multiple inflammatory markers based on real-time inputs and stored historical data;
- b. evaluating a mucosal integrity and damage by measuring moisture levels of exhaled air using multiple sensors, wherein the multiple sensors provide input to the inbuilt software program for comprehensive analysis;
- c. evaluating breathing function and obstruction by measuring a Forced Expiratory Volume in 1 second (FEV1) value, wherein FEV1 measurements are stored and processed by the inbuilt software program to compute FEV1 trends over time;
- d. evaluating a symptom control by determining a Chronic Obstructive Pulmonary Disease (COPD) Score, wherein the COPD Score is calculated using a multi-parameter computational model executed by the inbuilt software program, the multi-parameter model integrating data from the measured multiple inflammatory markers, computed FEV1 trends, evaluated mucosal integrity, and patient-reported symptom inputs scores;
- e. classifying the patient into one of a plurality of disease control categories based on the COPD Score, wherein each category is defined by a predefined numerical COPD Score range prestored in a memory of the device;
- and
- f. adjusting a treatment regimen for the respiratory disease by administering or modifying inhaled corticosteroid therapy when the classified COPD score range corresponds to a lower level of disease control.
Dependencies are inferred from the claim text.