Identification of protein biomarkers for diagnosis and treatment for sleep apnea

A method of diagnosing and treating Sleep Apnea (SA) in a patient, the method comprising:

• determining whether the patient needs a Polysomnography by:
• (a) obtaining a biological sample from the patient;
• and
• (b) determining if the sample comprises a previously determined level of an amino acid sequence comprising a sequence at least 95% identical to a protein selected from the group consisting of B3GNT2, LDHA, and H6PD/G6PE, wherein the previously determined level is a level of the amino acid sequence detected in a group of patients that tested positive for SA in a Polysomnography, wherein expression of the previously determined level of one of the proteins confirms that the patient needs a Polysomnography, and provides an initial diagnosis of SA in the patient;
• conducting a Polysomnography on the patient to confirm the initial diagnosis of SA;
• and
• when the initial diagnosis of SA is confirmed, treating the patient with a treatment of SA selected from the group consisting of ENT multilevel surgery, continuous positive airway pressure therapy, and bariatric surgery.