Methods for treating cerebral vasospasm with a PD-1 agonist
AssigneeThe Johns Hopkins University
InventorsMichael Lim, Christopher Jackson, Rafael J. Tamargo, John Choi
Life of this patent
Estimating the term…
Abstract
The present invention relates to the field of inflammation. More specifically, the present invention provides compositions and methods for treating cerebral inflammation and associated sequelae thereof including cerebral vasospasm. In one embodiment, a method for treating cerebral vasospasm in a patient comprises the step of administering to the patient a PD-1 agonist, wherein a blood sample obtained from the patient comprises elevated PD-1 expression on monocytes relative to a control.
Claims16
A method comprising:
- a. measuring programmed death-1 (PD-1) expression on monocytes in a blood sample obtained from a patient, wherein the patient has suffered a hemorrhagic or ischemic stroke;
- and
- b. treating the patient with soluble PD-L1 if the PD-1 expression is increased relative to a control.
A method comprising administering to a patient having an increased PD-1 expression on monocytes relative to a control soluble PD-L1, wherein the patient has suffered a hemorrhagic or ischemic stroke.
A method for treating cerebral vasospasm in a patient comprising the step of administering to the patient soluble PD-1, wherein a blood sample obtained from the patient comprises elevated PD-1 expression on monocytes relative to a control.
Dependencies are inferred from the claim text.