Determining WT-1-specific T cells and WT-1 specific T cell receptors (TCRS)
AssigneeAdaptive Biotechnologies Corporation
InventorsMarcos E. Milla, Mark Klinger, Peter J.R. Ebert, Timothy L. Hayes, Edward J. Osborne, Joyce K. Hu
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Abstract
The invention is directed to methods for determining antigen-specific T cells generally and to T cell receptors which bind an epitope of the Wilms' tumor antigen-1 (WT1) protein specifically. The disclosure also provides polynucleotides encoding the TCRs, engineered cells exogenously expressing the TCRs, and methods of making and using the TCRs and/or cells expressing the TCRs.
Claims8
One or more nucleic acids encoding a recombinant T cell receptor (TCR) that binds Wilms' tumor antigen-1 (WT1), wherein the recombinant TCR comprises an alpha chain and a beta chain, and wherein the beta chain comprises a CDR3 sequence comprising the amino acid sequence set forth in SEQ ID NO:
- 6, 14, 22, 30, 38, or 46.
Dependencies are inferred from the claim text.