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AssigneesThe Broad Institute, Inc., Beth Israel Deaconess Medical Center, Inc., Hebrew Seniorlife, Inc.
InventorsMelina Claussnitzer, Nasa Sinnott-Armstrong, Isabel Sousa, Samantha Laber, Douglas Kiel, Eric S. Lander
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Provided herein is a method for controlling a rate of fatty acid oxidation in mesenchymal cells, comprising modulating the expression or activity of ADCY5. The rate of fatty acid oxidation may be decreased by reducing the expression or activity of ADCY5. The rate of fatty acid oxidation may be increased by increasing the expression or activity of ADCY5. In some embodiments, the mesenchymal cell may be a mesenchymal stem cell, an adipocyte, an osteoblast, a chondrocyte, or a myocyte. In some embodiments, controlling the rate of fatty acid oxidation in mesenchymal stem cells comprises inhibiting fatty acid oxidation. In some embodiments, inhibiting fatty acid oxidation prevents development of Type 2 Diabetes (T2D). In some embodiments, controlling the rate of fatty acid oxidation in mesenchymal stem cells may comprise increasing the rate of fatty acid oxidation. Increasing the rate of fatty acid oxidation may promote bone formation.
A method of modulating fatty acid oxidation rate or osteoblast differentiation in a cell in vivo or in vitro, the method comprising:
A method of increasing or decreasing the expression or activity of adenylyl cyclase 5 (ADCY5) in a cell of a patient in need thereof to treat a metabolic disorder in the patient, the method comprising:
A method of modulating expression or activity of adenylyl cyclase 5 (ADCY5) in a cell of a subject in need thereof, wherein said modulating is capable of treating a metabolic disorder, regulating fasting glucose levels, or regulating bone growth rates, or any combination thereof, the method comprising contacting a mesenchymal stem cell (MSC)-derived cell of the subject with one or more modulating agents that modulate the expression or activity of ADCY5 in the cell of the subject;
Dependencies are inferred from the claim text.