Human pluripotent adult stem cells
OwnerShaowei Li, Min Hu +1inventors
InventorsShaowei Li, Min Hu, Bowen Liu
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Abstract
Certain populations of small cells present in adult human tissue can undergo activation/development to form human pluripotent stem cell populations. These small cells are generally less than six micrometers in diameter and are CD49f-positive, and are referred to herein as human early stage precursors or CD49f+ cells. Accordingly, provided are cell populations and compositions with enriched CD49f+ cells from adult human tissue samples and methods and compositions for promoting activation/development of these CD49f+ cells. Upon differentiation, the activated stem cells can be used for various therapeutic purposes.
Claims17
A method for culturing human cells that (a) have a diameter of less than 6 μm, and (b) express CD49f, comprising culturing the human cells in a medium that is in contact with or has been conditioned with primary hepatocytes and a hepatic cell line.
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