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US 12,644,096 B2Granted
Method for increasing romidepsin production from fermentation broth
AssigneePro Farm Group, Inc.
InventorsGian Oddone, Jacob Blodgett, Raul Reveles
Life of this patent
Estimating the term…
Abstract
The present invention includes a method to increase romidepsin concentration in a bacteria fermentation media. Romidepsin concentration in a fermentation is increased by adding, for example, copper sulfate. The end resulting romidepsin concentration is increased by at least about two fold as compare to fermentation without copper sulfate.
Claims1
A method of increasing romidepsin concentration in a bacterial fermentation comprising:
- fermenting a Chromobacterium haemolyticum or Burkholderia rinojensis bacterial strain in a fermentation medium comprising 0.1 g/L copper (II) sulfate, wherein said copper (II) sulfate increases romidepsin production compared to a fermentation that is identical but without the copper (II) sulfate in the medium.
Dependencies are inferred from the claim text.