Binding members
AssigneeScancell Limited
InventorsLinda Gillian Durrant, Mireille Vankemmelbeke, Tina Rose Parsons
Life of this patent
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Abstract
The present invention relates to specific binding members, such as antibodies and fragments thereof, that are capable of specifically binding a Lewis Y (Ley) carbohydrate. It also relates to the use of such binding members in medicine and to nucleic acids encoding such binding members.
Claims15
An isolated antibody or antibody fragment that binds specifically to Fuca1-2Galb1-4(Fuca1-3)GlcNAc (Ley), wherein the antibody or the antibody fragment comprises the following complementarity determining regions (CDRs):
- CDRH1, CDRH2 and CDRH3 having the amino acid sequences GFTFSHYY (SEQ ID NO:
- 63), ISNDGDNT (SEQ ID NO:
- 64), and ARGKYDGAWFAY (SEQ ID NO:
- 65), respectively, and
- CDRL1, CDRL2 and CDRL3 having the amino acid sequences QIIVHTNGNTY (SEQ ID NO:
- 66), KVS (SEQ ID NO:
- 67), and FQGSHVPFT (SEQ ID NO:
- 68), respectively.
An antibody or antibody fragment comprising a heavy chain having an amino acid sequence set forth in SEQ ID NO:
- 22 and a light chain having an amino acid sequence substantially as set forth in SEQ ID NO:
- 20.
Dependencies are inferred from the claim text.