Chimeric GMCSF-IL18 receptor
AssigneeSt. Jude Children's Research Hospital
InventorsStephen Gottschalk, Laurens Sand, Shannon Lange
Life of this patent
Estimating the term…
Abstract
The present invention provides chimeric cytokine receptors, particularly chimeric cytokine receptors that can be activated in tumor microenvironment, and their uses in tumor immunotherapy (e.g., adoptive cell therapy). The present invention further provides methods of genetically modifying therapeutic cells resulting in an enhanced immune response against a target antigen. The application further provides therapeutic cells that express said chimeric cytokine receptors and methods for treating patients using the modified therapeutic cells.
Claims44
A polynucleotide encoding a chimeric cytokine receptor, said chimeric cytokine receptor comprising two polypeptides, each comprising an extracellular domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor, or a functional portion thereof, a transmembrane domain, and an intracellular domain of interleukin-18 receptor (IL-18) receptor, or a functional portion thereof,
- wherein the chimeric cytokine receptor improves effector function when expressed in an immune cell expressing a chimeric antigen receptor (CAR), an antigen specific T cell receptor (TCR) and/or a bispecific antibody, relative to an immune cell not expressing the chimeric cytokine receptor.
A chimeric cytokine receptor, comprising two polypeptides, each comprising an extracellular domain of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor, or a functional portion thereof, a transmembrane domain, and an intracellular domain of interleukin-18 receptor (IL-18) receptor, or a functional portion thereof, wherein the chimeric cytokine receptor improves effector function when expressed in an immune cell expressing a chimeric antigen receptor (CAR), an antigen specific T cell receptor (TCR) and/or bispecific antibody, relative to an immune cell not expressing the chimeric cytokine receptor.
Dependencies are inferred from the claim text.