Engineered regulatory T cell
AssigneeUCL Business PLC
InventorsHans Stauss, Sharyn Thomas, Olivier Preham
Life of this patent
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Abstract
The present invention relates to an engineered regulatory T cell (Treg) comprising a T cell receptor (TCR) which is capable of specifically binding to a myelin basic protein (MBP) peptide or variant or fragment thereof when the peptide is presented by a major histocompatibility complex (MHC) molecule. The present invention further relates to methods for providing an engineered Treg and to methods and uses of said engineered Treg and vectors and kits of vectors encoding said Treg.
Claims9
An isolated engineered human regulatory T cell (Treg) comprising a T cell receptor (TCR) that is capable of specifically binding to a peptide comprising myelin basic protein (MBP) 82-102 (SEQ ID NO:
- 12) when the peptide is presented by a human leukocyte antigen D related (HLADR) B1*1501 molecule, wherein the TCR comprises an α chain and a β chain,
- wherein the α chain of the TCR comprises three complementarity determining regions (CDRs) having the following amino acid sequences:
- CDR1α
- (SEQ ID NO:
- 3)
- TSINN
- CDR2α
- (SEQ ID NO:
- 4)
- IRSNERE
- CDR3α
- (SEQ ID NO:
- 1)
- ATDTTSGTYKYI;
- and
- wherein the β chain of the TCR comprises three CDRs having the following amino acid sequences:
- CDR1β
- (SEQ ID NO:
- 5)
- DFQATT
- CDR2β
- (SEQ ID NO:
- 6)
- SNEGSKA
- CDR3β
- (SEQ ID NO:
- 2)
- SARDLTSGANNEQF.
Dependencies are inferred from the claim text.