Cardiac-specific targeting-peptide (CTP), compositions, and uses thereof
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorMaliha Zahid
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Abstract
Disclosed is a synthetic, non-naturally occurring 12-amino acid peptide, Cardiac Targeting Peptide, belonging to the larger class of cell penetrating peptides, for delivery of both diagnostic and potentially therapeutic agents to the heart. Also disclosed are subsequent generations of this Cardiac Targeting Peptide with improved, higher efficiency of cardiac uptake for CTP-mediated delivery of antiarrhythmics subjects for treating Atrial fibrillation or Ventricular fibrillation, CTP-mediated delivery of neuregulin-1β for treating systolic heart failure (SHF), and Szeto-Schiller peptides for treatment of diastolic congestive heart failure, among other applications.
Claims8
A compound consisting of a peptide covalently linked, via an ester linkage, a disulfide linker, a peptide bond, a thioester bond, or a carbamate bond, to a cargo selected from the group consisting of:
- a nucleic acid, a carbohydrate, a lipid, a small molecule, or a combination thereof, wherein the peptide consists of the amino acid sequence of SQYSRT (SEQ ID NO:
- 5).
A method of treating a human subject suffering from a cardiac condition selected from the group consisting of atrial arrhythmia and ventricular arrhythmia, the method comprising administering to the subject a therapeutically effective amount of a composition comprising a compound consisting of a peptide covalently linked via an ester linkage, a disulfide linker, a peptide bond, a thioester bond, or a carbamate bond to an anti-arrhythmic compound, wherein the peptide consists of the amino acid sequence of SQYSRT (SEQ ID NO:
- 5).
Dependencies are inferred from the claim text.