Ursolic acid preparations and uses thereof
AssigneeVirginia Commonwealth University
InventorPhillip Gerk
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Abstract
Ursolic acid (UA) preparations and a self-nanoemulsifying drug delivery system (SNEDDS) composition containing at least one UA preparation selected from monopotassium ursolate (UAK), dipotassium ursolate (UAK2), monocholine ursolate (UAmC), dicholine ursolate (UAdC), pharmacological salts thereof, and mixtures thereof are provided. Methods for synthesizing UA preparations and delivering UA preparations to subjects in need thereof are also provided.
Claims15
An ursolic acid salt, wherein the salt is dipotassium ursolate (UAK2) of formula:
An ursolic acid complex, wherein the complex is ursolic acid dicholine complex (UAdC-O) of formula:
An ursolic acid complex, wherein the complex is ursolic acid dicholine hydroxide hydrated complex (UAdC-W) of formula below, where the number of complexed water molecules ranges between 2 and 10:
A self-nanoemulsifying drug delivery system (SNEDDS) composition comprising:
- at least one ursolic acid (UA) preparation, wherein the at least one UA preparation is selected from the group consisting of dipotassium ursolate (UAK2), ursolic acid dicholine complex (UAdC-O), ursolic acid dicholine hydroxide hydrated complex (UAdC-W), pharmacological salts thereof, complexes thereof, and mixtures thereof;
- and
- at least two emulsifying agents.
A method of synthesizing ursolic acid dicholine hydroxide hydrated complex (UAdC-W), comprising:
- mixing ursolic acid and aqueous choline hydroxide in water to form a solution;
- heating the solution;
- cooling and incubating the solution at 20-25° C. until UAdC-W forms;
- and
- isolating UAdC-W.
Dependencies are inferred from the claim text.