Macrocyclic compounds, a process for their preparation and pharmaceutical compositions containing them

A compound of formula (IA1):

• wherein
• Z1 is —(CH2)n1—(CH2)n1—O— (CH2)n2— (CH2)n1—S— (CH2)n2,—(CH2)n1—NR—(CH2)n2—(CH2)n1—CHR′—(CH2)n2,—(CH2)n1—Ar1—(CH2)n2— (CH2)n1—Ar1—O— (CH2)n2— (CH2)n1—Ar1—S— (CH2)n2, —(CH2)n1—Ar1—CHR′—(CH2)n2,—Ar1—NR—(CH2)n1,
• or Z1 is
• Y1 is C;
• Y2 is O or NR′;
• Ar1 is optionally substituted aryl or optionally substituted heteroaryl;
• R is hydrogen, linear or branched C1-C3 alkyl or optionally substituted aryl;
• R′ is hydrogen, hydroxyl, optionally substituted aryl or linear or branched C1-C3 alkyl optionally substituted by alkoxy or by one to three halogen atoms;
• n1 and n2 each independently represent an integer from 1 to 6;
• R1, R2, R4, R8, R9, which may be identical or different, each represent hydrogen, halo, cyano, linear or branched C1-C3 alkyl optionally substituted by one to three halogen atoms, linear or branched C1-C3 alkoxy or optionally substituted aryl;
• R3 is hydrogen or linear or branched C1-C3 alkyl optionally substituted by one to three halogen atoms;
• or R2 and R3, together with the atoms bearing them, form a ring;
• its optical isomers, or addition salts thereof with a pharmaceutically acceptable base.