Method for synthesizing anti-tumor compound and intermediates thereof

A method for synthesizing an anti-tumor compound of formula 7, comprising the following steps:

• (a) subjecting a compound of formula 1 to an aromatic nucleophilic substitution reaction with a compound of formula 2M in an organic solvent under the action of a base to give a compound of formula IM, and subjecting the compound of formula IM, that is optionally separated, to another aromatic nucleophilic substitution reaction with a compound of formula 3, to give a compound of formula 4M;
• (b) subjecting the compound of formula 4M to a reduction reaction in an organic solvent under the action of a catalyst to give a compound of formula 5M;
• (c) subjecting the compound of formula 5M to a ring-closing reaction in an organic solvent under the action of an acid to give a compound of formula 6M;
• and
• (d) subjecting the compound of formula 6M to a reaction in an organic solvent to remove an amino-protecting group to give the anti-tumor compound of formula 7;
• the reaction scheme is as follows:
• wherein X1 and X2 are each chlorine;
• P1 is an amino-protecting group;
• P1 is linked to any N atom in a ring where P1 is located.