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US 12,643,846 B2Granted
Prodrugs of itaconate and methyl itaconate
AssigneesThe Johns Hopkins University, Institute of Organic Chemistry and Biochemistry of the AS CR, V.V.I.
InventorsBarbara Slusher, Mohameed Islam, Rana Rais, Luis Garza, Benjamin Bell, Pavel Majer, Lukas Tenora, Ivan Snajdr, Marcela Krecmerova
Life of this patent
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Abstract
Prodrugs of itaconic acid and 1- and 4-methyl itaconic acid and their use for treating a disease, disorder, or condition associated with inflammation are disclosed.
Claims4
A compound of formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein R1 and R2 are selected from one of the following combinations:
- (a) R1 is —OH and R2 is
- wherein u is an integer selected from 1, 2, 3 and 4, R20 is H, R21 is O—C1-6 alkyl;
- (b) R1 is O—C1-6 alkyl, and R2 is
- R4 is O—C1-6 alkyl, wherein n is an integer selected from 1, 2, 3 and 4;
- (c) R1 is
- wherein n is an integer selected from 1, 2, 3 and 4, and R2 is O—C1-6 alkyl;
- (d) R1 is
- wherein n is an integer selected from 1, 2, 3 and 4, and R2 is O—C1-6 alkyl;
- (e) R1 and R2 are
- wherein n is an integer selected from 1, 2, 3 and 4;
- (f) R1 is
- R4 is O—C1-6 alkyl, wherein n is an integer selected from 1, 2, 3 and 4, and R2 is O—C1-6 alkyl;
- and
- (g) R1 is
- wherein m is an integer selected from 1, 2, 3 and 4, R6 is CH3, p is an integer selected from 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, and 20, and R2 is O—C1-6 unsubstituted alkyl.
14 more elements
Dependencies are inferred from the claim text.