Microfluidic device for detecting nucleic acids
AssigneeKorea University Research and Business Foundation
InventorSe-Hyun Shin
Life of this patent
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Abstract
The microfluidic device for detecting nucleic acids includes: a chip main body; a sample chamber formed inside the chip main body and into which a sample is injected; a waste chamber spaced apart from the sample chamber and formed inside the chip main body; a connection conduit formed inside the chip main body to connect the sample chamber and the waste chamber to thereby form a flow path of the sample in the sample chamber, and having an inlet connected to the sample chamber and an outlet connected to the waste chamber; a nucleic acid detection layer provided at the inlet of the connection conduit and having at least one micropore passing therethrough in the flow direction of the sample; and a probe linker formed on the surface of the nucleic acid detection layer.
Claims7
A microfluidic device for detecting nucleic acids, the microfluidic device comprising:
- a chip body;
- a sample chamber defined in the chip body so as to receive a sample therein;
- a waste chamber spaced apart from the sample chamber and defined in the chip body;
- a connection channel defined in the chip body so as to connect the sample chamber and the waste chamber to each other, wherein the connection channel acts as a flow path of the sample in the sample chamber, and has an inlet connected to the sample chamber and an outlet connected to the waste chamber;
- a nucleic acid detection layer disposed perpendicular to the flow path of the sample at an interface between the sample chamber and the connection channel, wherein the nucleic acid detection layer is a single planar membrane having a plurality of micro-holes disposed therethrough;
- and
- a plurality of probe linkers disposed on a surface of the nucleic acid detection layer,
- wherein the probe linker is amplified via complementary binding to a target nucleic acid in the sample and detects the target nucleic acid.
Dependencies are inferred from the claim text.