Peripheral nerve and spinal cord differential target multiplexed stimulation

A computer-readable storage medium comprising instructions that, when executed, cause the processing circuitry to:

• control stimulation generation circuitry to:
• generate a first train of electrical stimulation pulses at a first frequency to a first target tissue;
• and
• generate a second train of electrical stimulation pulses at a second frequency to a second target tissue different from the first target tissue, wherein at least some electrical stimulation pulses of the first train of electrical stimulation pulses are interleaved with at least some electrical stimulation pulses of the second train of electrical stimulation pulses, wherein at least the first target tissue is associated with one of:
• a spinal cord of a patient, or one of a peripheral nerve or a nerve root of the patient, and wherein the second target tissue is associated with one of:
• the spinal cord of the patient, or one of the peripheral nerve or the nerve root of the patient;
• control sensing circuitry to detect, via an electrode combination at the second target tissue, an evoked compound action potential (ECAP) signal elicited by a first electrical stimulation pulse of the first train of electrical stimulation pulses to the first target tissue;
• determine a timing of the detection of the ECAP signal;
• and
• determine, based on the timing of the detection of the ECAP signal, a timing of delivery of subsequent electrical stimulation pulses of the first train of electrical stimulation pulses with respect to delivery of subsequent electrical stimulation pulses of the second train of electrical stimulation pulses.

A method comprising:

• generating, by stimulation generation circuitry, a first train of electrical stimulation pulses at a first frequency to a first target tissue;
• and
• generating, by the stimulation generation circuitry, a second train of electrical stimulation pulses at a second frequency to a second target tissue different from the first target tissue, wherein at least some electrical stimulation pulses of the first train of electrical stimulation pulses are interleaved with at least some electrical stimulation pulses of the second train of electrical stimulation pulses, wherein at least the first target tissue is associated with one of:
• a spinal cord of a patient, or one of a peripheral nerve or a nerve root of the patient, and wherein the second target tissue is associated with one of:
• the spinal cord of the patient, or one of the peripheral nerve or the nerve root of the patient;
• controlling, by processing circuitry, sensing circuitry to detect, via an electrode combination at the second target tissue, an evoked compound action potential (ECAP) signal elicited by a first electrical stimulation pulse of the first train of electrical stimulation pulses to the first target tissue;
• determining, by the processing circuitry, a timing of the detection of the ECAP signal;
• and
• determining, by the processing circuitry and based on the timing of the detection of the ECAP signal, a timing of delivery of subsequent electrical stimulation pulses of the first train of electrical stimulation pulses with respect to delivery of subsequent electrical stimulation pulses of the second train of electrical stimulation pulses.