Systems and methods for selective coating removal for resorbable metal medical devices
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsElia Beniash, Avinash Jagannath Patil
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Abstract
The invention relates to self-assembled organosilane coatings for resorbable medical implant devices. The coatings can be prepared from coating compositions containing organosilane and can be applied to metal or metal alloy substrates. Prior to applying the coatings, the surfaces of the substrates can be pretreated. The coatings can be functionalized with a binding compound that is coupled with an active component. The coatings can be selectively removed, e.g., patterned, to expose portions of the uncoated substrate. Selecting different patterns can provide the ability to regulate or control various properties, such as, corrosion and hydrogen generation.
Claims8
A medical implant device, comprising:
- a substrate composed of a material selected from the group consisting of magnesium and magnesium alloy having an outer surface;
- a thin film, self-assembled coating applied to the outer surface of the substrate, the self-assembled coating comprising:
- a laminar structure;
- a plurality of layers;
- a hybrid amphiphilic alkylsilane consisting of a hydrophobic aliphatic tail with a C4 to C20 aliphatic backbone and a hydrophilic silane head reactive with the substrate;
- and
- a cross-linking agent combined with the alkylsilane,
- wherein the coating has a thickness of about 1 um;
- an aminosilane binding compound attached to the surface of the self-assembled coating;
- and
- an active component coupled to the aminosilane binding compound,
- wherein the self-assembled coating reduces degradation rate of the substrate.
Dependencies are inferred from the claim text.