Biomaterials for enhanced implant-host integration
AssigneesMassachusetts Institute of Technology, The Trustees of the University of Pennsylvania
InventorsChristopher S. Chen, Jan D. Baranski, Ritika Chaturvedi, Michael T. Yang, Kelly Stevens, Sangeeta Bhatia
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Abstract
The present disclosure provides patterned biomaterials having organized cords and extracellular matrix embedded in a 3D scaffold. According, the present disclosure provides compositions and applications for patterned biomaterials. Pre-patterning of these biomaterials can lead to enhanced integration of these materials into host organisms, providing a strategy for enhancing the viability of engineered tissues by promoting vascularization.
Claims9
A method of enhancing the survival and/or function of hepatocytes following implantation, comprising:
- (1) providing a patterned biomaterial comprising:
- (a) at least one cord, formed by embedding cells in a naturally-derived or synthetic scaffolding with a pre-specified architecture and spatially organizing the cells within the scaffolding, wherein the cells embedded in the naturally-derived or synthetic scaffolding consists of endothelial cells;
- and
- (b) at least one cluster of hepatocytes;
- and
- (2) implanting the patterned biomaterial into a tissue of the subject, wherein the patterned biomaterial is configured to promote the vascularization of the patterned biomaterial and the tissue of the subject, wherein the structure of the patterned biomaterial has a pre-specified architecture that acts as a template and spatial guidance for the subject's vasculature, thereby enhancing the survival and/or function of the hepatocytes following implantation.
Dependencies are inferred from the claim text.