POSS viscoelastic hemostatic agents
AssigneeHybrid Plastics, Inc.
InventorJoseph D. Lichtenhan
Life of this patent
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Abstract
A fluidic hemostat agent comprising a solid hemostatic additive suspended in a silanol carrier fluid to form a heterogeneous mixture that exhibits sufficient flowability to allow for injection and proliferation, while simultaneously having sufficient adhesive and viscoelastic characteristics to remain at the application site and enable the clotting cascade time to form a thrombus. The silanol carrier fluid preferably comprises liquid silanol-bearing POSS molecules, while the solid hemostatic additive preferably is selected from the group consisting of kaolin, chitin, chitosan, cellulose, keratin pectin, acetylated glucosamine, dry fibrin, gelatin, and calcium salts. A preferred silanol species is iso-octylPOSS trisilanol having the molecular representation [(i-ocylSiO1.5)4(i-octyl(OH)SiO1.0)3]Σ7.
Claims19
A fluidic hemostatic agent comprising:
- a) a silanol carrier fluid;
- and
- b) a solid hemostatic additive suspended in the silanol carrier fluid, wherein the solid hemostatic additive is selected from the group consisting of kaolin, chitin, chitosan, cellulose, keratin pectin, acetylated glucosamine, dry fibrin, gelatin, or calcium salts;
- c) wherein the fluidic hemostatic agent exhibits a viscosity that varies as a function of applied shear rate.
A fluidic hemostatic agent comprising:
- a) a silanol carrier fluid, wherein the silanol carrier fluid comprises a silanol-bearing composition selected from the group consisting of polyhedral oligomeric silsesquioxanes, silsesquioxanes, silicones, and silicates;
- and
- b) a solid hemostatic additive suspended in the silanol carrier fluid;
- c) wherein the fluidic hemostatic agent exhibits a viscosity that varies as a function of applied shear rate.
A process for treating a hemorrhaging wound site, the process comprising:
- a) providing a fluidic hemostatic agent comprising a solid hemostatic additive suspended in i-octylPOSS trisilanol, wherein the solid hemostatic additive is selected from the group consisting of kaolin, chitin, chitosan, cellulose, keratin pectin, acetylated glucosamine, dry fibrin, gelatin, or calcium salts, wherein the fluidic hemostatic agent exhibits a viscosity that varies as a function of applied shear rate;
- and
- b) applying the fluidic hemostatic agent mixture to the wound site.
Dependencies are inferred from the claim text.