Injectable and in-situ crosslinking hydrogel for endovascular embolization
AssigneeWisconsin Alumni Research Foundation
InventorsShaoqin Gong, Ruosen Xie, Dai Yamanouchi
Life of this patent
Estimating the term…
Abstract
The present technology provides a composition comprising a mixture of a source of calcium ions, alginate conjugated to an acrylate monomer (ALG-A), carboxymethylcellulose conjugated to an acrylate monomer (CMC-A) and water, wherein the mixture is a shear-thinning gel. The compositions may further include a polythiol agent. Such compositions are injectable due to their shear-thinning properties, yet stay in place, undergo in situ crosslinking, and provide safe, simple and efficacious endovascular embolization. Methods of making and using such compositions are also provided.
Claims28
A composition comprising a mixture of a source of calcium ions, alginate conjugated to an acrylate monomer (ALG-A), carboxymethylcellulose conjugated to an acrylate monomer (CMC-A) and water, wherein the mixture is a shear-thinning gel, and wherein the composition comprises 0.1 wt % to 10 wt % of a source of calcium ions.
A method of making a composition comprising mixing alginate conjugated to an acrylate monomer (ALG-A), carboxymethylcellulose conjugated to an acrylate monomer (CMC-A) and a source of calcium ions in water to provide a shear-thinning gel, wherein the composition comprises 0.1 wt % to 10 wt % of a source of calcium ions.
Dependencies are inferred from the claim text.