Composition for immune tolerance induction and use in gene therapy
AssigneeThe Research Foundation for The State University of New York
InventorSathy V. Balu-Iyer
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Abstract
Provided are compositions and methods for reducing pre-existing antibodies against viral vector or gene-editing related proteins. The compositions showed reduction in various antibody titers by administration of a liposome composition complexed with a protein or fragment thereof of a viral vector. The liposomes comprise phosphatidylcholine and phosphatidylserine, wherein some or all of the PS is present as lyso-PS. The compositions and methods can be used in conjunction with gene therapy and nucleic acid based vector based vaccinations and therapeutics.
Claims5
A method of reducing generation of antibodies against a viral vector protein comprising administering to an individual in need of treatment a composition comprising liposomes, wherein the liposomes comprise phosphatidylcholine (PC) and lysophosphatidylserine (lyso-PS), wherein the ratio of PC to lyso-PS is from 90:10 to 60:40, wherein some or all of the PS is present as lyso-PS and wherein the liposomes are complexed to the viral vector protein or an antigenic fragment thereof, wherein the viral vector protein or antigenic fragment thereof comprises the sequence
- (SEQ ID NO:
- 1)
- IVADNLQQNTAPQIG.
Dependencies are inferred from the claim text.