Long-lasting hydrogel for use against drug-resistant bacteria and preparation method and use thereof

A preparation method of a long-lasting hydrogel for use against drug-resistant bacteria, comprising the following steps:

• 1) preparation of a polyvinyl alcohol (PVA) solution by dissolving a PVA in deionized water to obtain a first mixture solution, and heating and stirring the first mixture solution to obtain the PVA solution, wherein the heating and stirring in step 1) is conducted at 60° C. for 24 h at a rotational speed of 800 rpm/min;
• 2) preparation of a mixed solution by mixing the PVA solution, a phytic acid solution, and honey in a mass ratio of 5:5:2 to obtain a second mixture solution, heating and stirring the second mixture solution to promote formation of intermolecular interactions among the PVA solution, the phytic acid solution, and the honey, including ester bonds, hydrogen bonds, and electrostatic interactions, thereby obtaining a third mixture solution, and allowing the third mixture solution to stand for bubble removal to obtain a transparent mixed solution, wherein the phytic acid solution has a mass percentage concentration of 1% to 5%, and the heating and stirring in step 2) is conducted at 70° C. and 700 rpm/min;
• 3) pre-curing treatment of the transparent mixed solution by pre-curing the transparent mixed solution under heating in an 80° C. water bath to promote further formation of the intermolecular interactions among the PVA solution, the phytic acid solution, and the honey, including the ester bonds, the hydrogen bonds, and the electrostatic interactions, thereby obtaining a pre-cured hydrogel solution;
• and
• 4) preparation of an antimicrobial hydrogel by pouring the pre-cured hydrogel solution into a prepared mold, and conducting three freeze-thaw cycles to obtain a cured hydrogel.