Near-infrared (NIR) absorbing photosensitizers
AssigneesOrta Dogu Teknik Universitesi, Koc Universitesi
InventorsGorkem Gunbas, Safacan Kolemen, Osman Karaman, Gizem Atakan, Toghrul Almammadov
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Abstract
Near-infrared (NIR) absorbing photosensitizers for imaging and treatment of cancer in a photodynamic therapy (PDT) are provided. Specifically, the NIR photosensitizers are mitochondria targeted and water-soluble, and used as a cytotoxic drug in a photodynamic therapy of the cancer. The NIR photosensitizers are activated with wavelengths of light, wherein the light penetrates through a body not just a skin. Hence the NIR photosensitizers aim to transform PDT from being a specialized treatment to a generally applicable one. PDT is almost completely non-invasive compared to current treatment methods.
Claims6
A NIR absorbing photosensitizer, comprising formula C or D or E or F or G,
- wherein;
- wherein
- R3=alkyl;
- R4=—H, —Br, —I, alkyl;
- R5=—H, —Br, —I, alkyl;
- R6=—H, —Br, —I, alkyl;
- R7=—H, —Br, —I;
- R8=—H, —Br, —I, alkyl;
- R9=—H, —Br, —I, alkyl;
- R10=—H, —Br, —I, alkyl;
- and
- R11=—H, —Br, —I, alkyl;
- wherein
- R3=alkyl;
- R4=—H, —Br, —I, alkyl;
- R5=—H, —Br, —I, alkyl;
- R6=—H, —Br, —I, alkyl;
- R7=—H, —Br, —I, alkyl;
- R8=—H, —Br, —I, alkyl;
- R9=—H, —Br, —I, alkyl;
- R10=—H, —Br, —I, alkyl;
- and
- R11=—H, —Br, —I, alkyl;
- wherein;
- wherein
- R3=alkyl;
- R4=alkyl;
- R5=alkyl;
- R6=—H, —Br, —I, alkyl;
- R7=—H, —Br, —I, alkyl;
- R8=—H, —Br, —I, alkyl;
- R9=—H, —Br, —I, alkyl;
- R10=—H, —Br, —I, alkyl;
- R11=—H, —Br, —I, alkyl;
- R12=—H, —Br, —I, alkyl;
- and
- R13=—H, —Br, —I, alkyl;
- wherein
- R5=alkyl;
- R6=—H, —Br, —I, alkyl;
- R7=—H, —Br, —I, alkyl;
- R8=—H, —Br, —I, alkyl;
- R9=—H, —Br, —I, alkyl;
- R10=—H, —Br, —I, alkyl;
- R11=—H, —Br, —I, alkyl;
- R12=—H, —Br, —I, alkyl;
- and
- R13=—H, —Br, —I, alkyl;
- wherein;
- R1 is an alkyl (R), R2 is an alkyl (R),
- wherein
- R3=alkyl;
- R4=alkyl;
- R5=alkyl;
- R6=—H, —Br, —I, alkyl;
- R7=—H, —Br, —I, alkyl;
- R8=—H, —Br, —I, alkyl;
- R9=—H, —Br, —I, alkyl;
- R10=—H, —Br, —I, alkyl;
- R11=—H, —Br, —I, alkyl;
- R12=—H, —Br, —I, alkyl;
- and
- R13—H, —Br, —I, alkyl;
- wherein
- R5=alkyl;
- R6=—H, —Br, —I, alkyl;
- R7=—H, —Br, —I, alkyl;
- R8=—H, —Br, —I, alkyl;
- R9=—H, —Br, —I, alkyl;
- R10=—H, —Br, —I, alkyl;
- R11=—H, —Br, —I, alkyl;
- R12=—H, —Br, —I, alkyl;
- and
- R13=—H, —Br, —I, alkyl;
- wherein;
- wherein
- R2=alkyl;
- R3=—H, —Br, —I, alkyl;
- R4=—H, —Br, —I, alkyl;
- R5=—H, —Br, —I, alkyl;
- R6=—H, —Br, —I, alkyl;
- R7=—H, —Br, —I, alkyl;
- R8=—H, —Br, —I, alkyl;
- R9=—H, —Br, —I, alkyl;
- and
- R10=—H, —Br, —I, alkyl;
- wherein
- R2=alkyl;
- R3=—H, —Br, —I, alkyl;
- R4=—H, —Br, —I, alkyl;
- R5=—H, —Br, —I, alkyl;
- R6=—H, —Br, —I, alkyl;
- R7=—H, —Br, —I, alkyl;
- R8=—H, —Br, —I, alkyl;
- R9=—H, —Br, —I, alkyl;
- and
- R10=—H, —Br, —I, alkyl;
- wherein
- R1 is an alkyl (R);
- wherein
- R3=alkyl;
- R4=alkyl;
- R5—H, —Br, —I, alkyl;
- R6=—H, —Br, —I, alkyl;
- R7=—H, —Br, —I, alkyl;
- R8=—H, —Br, —I, alkyl;
- R9=—H, —Br, —I, alkyl;
- R10=—H, —Br, —I, alkyl;
- R11=—H, —Br, —I, alkyl;
- and
- R12=—H, —Br, —I, alkyl;
- wherein
- R4=alkyl;
- R5=—H, —Br, —I, alkyl;
- R6=—H, —Br, —I, alkyl;
- R7=—H, —Br, —I, alkyl;
- R8=—H, —Br, —I, alkyl;
- R9=—H, —Br, —I, alkyl;
- R10=—H, —Br, —I, alkyl;
- R11=—H, —Br, —I, alkyl;
- and
- R12=—H, —Br, —I, alkyl.
Dependencies are inferred from the claim text.