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US 12,642,848 B2Granted
Immunogenic trimers
AssigneesInternational AIDS Vaccine Initiative, The Scripps Research Institute
InventorsJon Steichen, Dan Kulp, Xiaozhen Hu, Sergey Menis, William Schief, Sebastian Raemisch
Life of this patent
Estimating the term…
Abstract
The invention relates to PGT121-germline-targeting designs, trimer stabilization designs, combinations of those two, trimers designed with modified surfaces helpful for immunization regimens, other trimer modifications and on development of trimer nanoparticles and methods of making and using the same.
Claims9
A non-naturally occurring protein comprising an immunogen comprising a human immunodeficiency virus type 1 (HIV-1) gp120 or gp140 trimer comprising:
- (a) one or more mutations selected from the group consisting of T106E, M271I, F288L, T290A, N363Q, F519S, A561P, L568D, V570H, or R585H that improve thermostability;
- and
- (b) one or more mutations selected from the group consisting of T135A, T139I, V134Y, N136P, I138L, D140N, N137F, T320F, and Q328M that maintain binding to broadly neutralizing antibodies while reducing binding to non-neutralizing antibodies;
- wherein the amino acid residue positions for said mutations are numbered according to the sequence of the HIV-1 BG505 Env sequence as set forth in SEQ ID NO:
- 139.
2 more elements
Dependencies are inferred from the claim text.