Zika/dengue vaccine and application thereof
AssigneeInstitute of Microbiology, Chinese Academy of Sciences
InventorsFu Gao, Lianpan Dai, Jinghua Yan, Kun Xu, Yuxuan Han, Qihui Wang, Qingrui Huang, Jinhe Li
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Abstract
Provided in the present disclosure are a Zika/dengue vaccine and its application thereof. The present disclosure introduces a mutation into the E-protein FL fusion region of the Zika virus or dengue virus. Antigens with said mutations are unable to bind to antibodies that causes ADE. After immunization with the vaccine of the present disclosure acquired from the said antigens, production of FL epitope-induced antibodies can be prevented, thereby reducing or eliminating the ADE effect.
Claims3
An antigen comprising a Zika virus E protein, wherein an amino acid sequence of the E protein comprises SEQ ID NO. 1 having the mutations D98N, N103T, G106F, L107K and F108W.
Dependencies are inferred from the claim text.