PD1-based vaccination composition and methods thereof
AssigneeVersitech Limited
InventorsZhiwei Chen, Zhiwu Tan
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Abstract
Provided herein is DNA vaccine and composition comprising PD1-based TWIST1. Also provided is a method for inducing TWIST1-specific T cell response by administering a PD1-based TWIST1 vaccine. Also provided is a method for inducing TWIST1-specific T cell response by administering a PD1-based TWIST1 vaccine and an immune checkpoint inhibitor.
Claims14
A DNA vaccine construct encoding a fusion protein comprising soluble PD1 linked with TWIST1, and wherein the fusion protein comprises a TWIST1 peptide consisting of the amino acid sequence of SEQ ID NO:
- 4.
A composition comprising a DNA vaccine construct encoding a fusion protein comprising:
- (i) a soluble PD1;
- and (ii) TWIST1, wherein the soluble PD1 is linked to the TWIST1;
- and an acceptable pharmaceutical carrier, and wherein the fusion protein comprises a TWIST1 peptide consisting of the amino acid sequence of SEQ ID NO:
- 4.
A kit comprising a DNA vaccine construct encoding a fusion protein comprising (i) a soluble PD1;
- and (ii) TWIST1, wherein the soluble PD1 is linked to the TWIST1;
- and an acceptable pharmaceutical carrier, and wherein the fusion protein comprises a TWIST1 peptide consisting of the amino acid sequence of SEQ ID NO:
- 4.
A method for inducing TWIST1-specific T cell response in a subject having TWIST1 overexpressed cancer, comprising administering to the subject an effective amount of a DNA vaccine comprising a DNA construct encoding a fusion protein comprising soluble PD1 linked with TWIST1, wherein the fusion protein comprises a TWIST1 peptide consisting of the amino acid sequence of SEQ ID NO:
- 4.
Dependencies are inferred from the claim text.