Mucoadhesive microgel compositions and methods for using the same
AssigneesThe Board of Trustees of the Leland Stanford Junior University, Universite De Pau Et Des Pays De L'adour, Centre National De La Recherche Scientifique
InventorsLaurent Billon, Eva Dieuzy, Garbine Aguirre, Solange Massa, Peter Luke Santa Maria
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Abstract
Mucoadhesive microgel compositions, which include an active agent (such as HB-EGF), are provided. Aspects of the invention include a microgel comprising a crosslinked poly(ethylene glycol) methyl ether methacrylate polymer comprising a mucoadhesive functionality. Also provided are methods of making and using the mucoadhesive microgel compositions, e.g., in therapeutic applications. In one embodiment, HB-EGF loaded mucoadhesive microgel compositions are provided, e.g., for prevention or treatment of mucositis conditions, such as therapy induced oral mucositis conditions.
Claims15
A mucoadhesive microgel therapeutically active agent composition comprising a therapeutically active agent loaded into a mucoadhesive cross-linked microgel comprising a crosslinked poly(ethylene glycol) methyl ether methacrylate polymer comprising a mucoadhesive functionality, wherein the crosslinked poly(ethylene glycol) methyl ether methacrylate polymer consists of diethylene glycol methacrylate monomeric units, oligoethylene glycol methacrylate monomeric units, methacrylic acid monomeric units, dopamine acrylamide monomeric units, and crosslink moieties,
- wherein the therapeutically active agent is heparin binding epidermal growth factor (HB-EGF),
- wherein the mucoadhesive microgel is suitable for treating radiotherapy or chemotherapy-induced oral mucositis, and
- wherein the crosslink moieties are selected from the group consisting of oligo(ethylene glycol) diacrylate comprising from 1 to 10 ethylene glycol units, poly(propylene glycol) diacrylate, ethylene glycol dimethacrylate, glycerol dimethacrylate, N,N′-methylenebisacrylamide, N,N-(1,2-dihydroxyethylene)bisacrylamide, poly(ethylene glycol)diacrylamide, bis(2-methacryloyl)oxyethyl disulfide and N,N-bis(acryloyl) cystamine, and crosslink moieties having di(meth)acrylate end groups and a moiety selected in the group consisting of —(CH2—CH2—O)n—CH2—CH2—where n is from 0 to 6, —NH—CH2—NH— and mixtures thereof.
Dependencies are inferred from the claim text.