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AssigneeMangoGen Pharma, Inc.
InventorsSatya Prakash, Arghya Paul, Dominique Shum-Tim
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The present disclosure provides viral microparticles comprising genetically-engineered baculoviruses (at least partially) embedded in a polymeric matrix for the local delivery of therapeutic nucleic acid molecules to the cells of a vertebrate individual (optionally in combination with a medical implant such as vascular stent platform). The viral microparticles are especially useful for promoting the healing of a wound as well as the repair of a blood vessel and prevent pathological scarring. Also provided herein are processes for making the viral microparticles, pharmaceutical compositions comprising viral microparticles as well as sup-ports comprising the viral micro particles for the locating the viral microparticles in a wound or in the vicinity of a wound.
A pharmaceutical product for nucleic acid delivery, the pharmaceutical product comprising a component in or on which a viral microparticle is disposed, the component selected from a suture, support, gelling agent or topical composition, the viral microparticle comprising a genetically-engineered baculovirus having a viral genome comprising the nucleic acid and lacking the ability of replicating in the cells of a vertebrate individual.
Dependencies are inferred from the claim text.