Selection and use of melatonin supporting bacteria to reduce infantile colic
AssigneeBiogaia AB
InventorsStefan Roos, Bo Möllstam
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Abstract
The present invention relates to lactic acid bacterial strains which are capable of producing or inducing the production of melatonin, for use in the production of melatonin in a subject. Preferred strains for such uses are capable of producing or inducing the production of adenosine. Therapeutic uses of such strains include the treatment or prevention of diseases associated with melatonin deficiency, for example infantile colic. Novel strains are also provided.
Claims4
A method of treating sleep disturbances or sleep disorders associated with deficiencies in melatonin or melatonin balance in a subject, comprising administering to the subject a therapeutically effective amount of Lactobacillus reuteri DSM 32846, DSM 32847, DSM 32849 and/or DSM 33198;
- wherein said Lactobacillus reuteri DSM 32846, DSM 32847, DSM 32849 and/or DSM 33198 has 5′-nucleotidase activity, and/or produces or induces the production of adenosine, and/or produces or induces the production of melatonin, at a level which is increased as compared to Lactobacillus reuteri DSM 17938.
Dependencies are inferred from the claim text.