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US 12,642,819 B2Granted
Compositions and methods for treating inflammatory bowel disease
AssigneeIcahn School of Medicine at Mount Sinai
InventorsGraham J. Britton, Jeremiah J. Faith
Life of this patent
Estimating the term…
Abstract
The present invention provides methods of diagnosing, treating, and monitoring the progression of inflammatory bowel disease in a subject, including, for example, by monitoring RORγt+Th or RORγt+Treg cell levels and treating the subject accordingly.
Claims6
A method of treating inflammatory bowel disease in a subject comprising:
- administering to said subject a therapeutic composition comprising a bacterial community consisting essentially of:
- a Bacteroides dorei strain, wherein said Bacteroides dorei strain is represented by SEQ ID NO:
- 4;
- a Bacteroides fragilis strain, wherein said Bacteroides fragilis strain is represented by SEQ ID NO:
- 5;
- a Bacteroides ovatus strain, wherein said Bacteroides ovatus strain is represented by SEQ ID NO:
- 7;
- a Bacteroides thetaiotaomicron strain, wherein said Bacteroides thetaiotaomicron strain is represented by SEQ ID NO:
- 10;
- a Bifidobacterium adolescentis strain, wherein said Bifidobacterium adolescentis strain comprising SEQ ID NO:
- 17;
- a first Bifidobacterium longum strain, wherein said first Bifidobacterium longum strain is represented by SEQ ID NO:
- 23;
- a second Bifidobacterium longum strain, wherein said second Bifidobacterium longum strain is represented by SEQ ID NO:
- 24;
- a Bifidobacterium pseudocatenulatum strain, wherein said Bifidobacterium pseudocatenulatum strain is represented by SEQ ID NO:
- 27;
- a Butyricicoccus p. strain, wherein said Butyricicoccus sp. strain is represented by SEQ ID NO:
- 29;
- a Clostridium sp. strain, wherein said Clostridium sp. strain is represented by SEQ ID NO:
- 34;
- a Collinsella aerofaciens strain, wherein said Collinsella aerofaciens strain is represented by SEQ ID NO:
- 36;
- a Escherichia coli strain, wherein said Escherichia coli strain is represented by SEQ ID NO:
- 43;
- a Lactobacillus casei strain, wherein said Lactobacillus casei strain is represented by SEQ ID NO:
- 47;
- a Parabacteroides distasonis strain, wherein said Parabacteroides distasonis strain is represented by SEQ ID NO:
- 50;
- and a Ruminococcus torques strain, wherein said Ruminococcus torques strain is represented by SEQ ID NO:
- 55.
28 more elements
A method of treating a disease in a subject by administering a therapeutic composition that stimulates RORyt+Treg cell production in said subject, wherein said therapeutic composition comprises a bacterial community consisting essentially of:
- a Bacteroides dorei strain, wherein said acteroides dorei strain is represented by SEQ ID NO:
- 4;
- a Bacteroides fragilis strain, wherein said Bacteroides fragilis strain is represented by SEQ ID NO:
- 5;
- a Bacteroides ovatus strain, wherein said Bacteroides ovatus strain is represented by SEQ ID NO:
- 7;
- a Bacteroides thetaiotaomicron strain, wherein said Bacteroides thetaiotaomicron strain is represented by SEQ ID NO:
- 10;
- a Bifidobacterium adolescentis strain, wherein said Bifidobacterium adolescentis strain comprising SEQ ID NO:
- 17;
- a first Bifidobacterium longum strain, wherein said first Bifidobacterium longum strain is represented by SEQ ID NO:
- 23;
- a second Bifidobacterium longum strain, wherein said second Bifidobacterium longum strain is represented by SEQ ID NO:
- 24;
- a Bifidobacterium pseudocatenulatum strain, wherein said Bifidobacterium pseudocatenulatum strain is represented by SEQ ID NO:
- 27;
- a Butyricicoccus sp. strain, wherein said Butyricicoccus sp. strain is represented by SEQ ID NO:
- 29;
- a Clostridium sp. strain, wherein said Clostridium sp. strain is represented by SEQ ID NO:
- 34;
- a Collinsella aerofaciens strain, wherein said Collinsella aerofaciens strain is represented by SEQ ID NO:
- 36;
- a Escherichia coli strain, wherein said Escherichia coli strain is represented by SEQ ID NO:
- 43;
- a Lactobacillus casei strain, wherein said Lactobacillus casei strain is represented by SEQ ID NO:
- 47;
- a Parabacteroides distasonis strain, wherein said Parabacteroides distasonis strain is represented by SEQ ID NO:
- 50;
- and a Ruminococcus torques strain, wherein said Ruminococcus torques strain is represented by SEQ ID NO:
- 55.
27 more elements
Dependencies are inferred from the claim text.