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US 12,642,807 B2Granted
Methods and compositions for treating and preventing skin barrier disruptions
AssigneeDermafence Ltd
InventorShulamit Richter Dayan
Life of this patent
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Abstract
The present invention provides compositions and methods for treating, or attenuating and/or preventing skin barrier disruptions, skin insults and skin conditions in a subject. The lyotropic liquid crystal composition of the invention comprises at least one of phase changing material, and at least one stratum corneum component.
Claims21
A homogenic anisotropic lyotropic liquid crystal product with endothermic properties, for topical application directly to skin of a mammal, mimicking a mammalian stratum corneum skin barrier, comprising:
- at least 50 wt % of at least one phase changing material (PCM) and at least one stratum corneum (SC) component, and less than 40 wt % hydrant, said lyotropic liquid crystal product comprising a fatty acid, a fatty acid salt hydrate, or a fatty acid salt,
- wherein the PCM and SC components are selected such that the product is in the form of a homogenic anisotropic lyotropic liquid crystal phase with endothermic properties, mimicking a mammalian stratum corneum skin barrier.
Dependencies are inferred from the claim text.