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AssigneeCardiol Therapeutics Inc.
InventorsAnthony Ernest Bolton, Blagoja Ristevski, Guillermo Torre Amione, Gerardo De Jesús García Rivas, Omar Lozano García, Eldon Raymond Smith
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A pharmaceutical composition containing an effective amount of cannabidiol (CBD) for use in treating or preventing a heart condition, along with related methods and uses. The heart conditions include heart failure, acute myocarditis, toxicity caused by anti-cancer therapies, acute pericarditis, cardiac sarcoidosis, inflammatory cardiomyopathy, and atherosclerosis and related uses and methods. The disclosure shows CBD to be effective in (i) reducing cardiac hypertrophy; (ii) reducing cardiac fibrosis; (iii) reducing the level of BNP; (iv) reducing the level of cytokine IL1β; (v) reducing the level of cytokine IL6; (vi) reducing the level of CD69; (vii) increasing the level of cytokine IL10, and (viii) combinations thereof. The composition is preferably adapted for parenteral administration.
A method of treating or preventing a heart condition selected from the group consisting of heart failure, myocarditis, toxicity caused by anti-cancer therapies, acute pericarditis, cardiac sarcoidosis, inflammatory cardiomyopathy, and atherosclerosis in a subject in need thereof, the method comprising administering an effective amount of cannabidiol (CBD) to the subject, wherein the administration of the CBD effects (i) a reduction of a level of B-type natriuretic peptide (BNP), (ii) a reduction of a level of cluster of differentiation 69 (CD69), (iii) an increase in a level of cytokine interleukin 10 (IL10), or (iv) a combination of any of (i) to (iii) in the subject.
Dependencies are inferred from the claim text.