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US 12,642,804 B2Granted
Method of treating microbial infections
AssigneeThe Regents of the University of California
InventorsRichard L. Gallo, Teruaki Nakatsuji
Life of this patent
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Abstract
The disclosure provides for novel antimicrobial agents, methods of making, and methods of use thereof.
Claims7
A pharmaceutical composition comprising firmocidin, wherein the pharmaceutical composition is formulated for topical administration, and wherein the pharmaceutical composition comprises one or more additional therapeutic agents, and wherein the firmocidin is isolated by:
- obtaining a supernatant derived from cultured Staphylococcus epidermidis strain MO34;
- subjecting the supernatant to high pressure column fractionation to obtain purified fractions;
- and
- isolating the purified fraction having a molecular formula of C5H5N5O and having a molecular weight of 152.0567 Da to obtain firmocidin.
1 more element
A pharmaceutical composition comprising firmocidin, wherein the pharmaceutical composition is formulated for topical administration, wherein the firmocidin is isolated by:
- obtaining a supernatant derived from cultured Staphylococcus epidermidis strain MO34;
- subjecting the supernatant to high pressure column fractionation to obtain purified fractions;
- and
- isolating the purified fraction having a molecular formula of C5H5N5O and having a molecular weight of 152.0567 Da to obtain firmocidin.
1 more element
Dependencies are inferred from the claim text.