US 12,642,795 B2 · MRGPRX2 antagonist for the treatment of pseudo allergic reactions

Abstract

Compounds that have antiallergic and/or anti-inflammatory properties and methods of making thereof are disclosed. These compounds can block MMRGPRX2 and prevent or reduce mast cells activation. Pharmaceutical formulations in a unit dosage form suitable for the delivery of the compounds to a subject in need thereof are disclosed. The pharmaceutical formulations may include one or more active agents in addition to the compounds, such as one or more additional antiallergic and/or anti-inflammatory agents. The pharmaceutical formulation can be administered by oral administration, parenteral administration, inhalation, mucosal administration, or a combination thereof. Methods for preventing or treating pseudo allergic reactions, pseudo allergic diseases, and/or pseudo inflammatory diseases, or treating or ameliorating one or more symptoms associated with a pseudo allergic reaction, a pseudo allergic disease, and/or a pseudo inflammatory disease in a subject are also disclosed.

Claims24

Dependent claims

A compound having the structure of

(a) wherein n is 0 or 1;
(b) wherein R′ and R″ are independently a hydrogen or an unsubstituted alkyl;
(c) wherein
has the structure of
(d) wherein
has the structure of
(e) wherein each occurrence of Y′ is independently CR1, O, S, or NR2, R1 and R2 are independently a hydrogen, an unsubstituted alkyl, a carbonyl, an alkoxy, an amido, an amino, an oxo, a thiol, or a hydroxyl,
with the proviso that when G′ and E′ are substituted aryl, the substituent is not an alkoxy.

5 more elements

Dependencies are inferred from the claim text.

MRGPRX2 antagonist for the treatment of pseudo allergic reactions

Life of this patent

MRGPRX2 antagonist for the treatment of pseudo allergic reactions

Life of this patent

Abstract

Claims24