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US 12,642,773 B2Granted
Coated drug compositions and methods of preparing the same
AssigneeApplied Materials, Inc.
InventorsFei Wang, Miaojun Wang, Balaji Ganapathy, Jonathan Frankel, Shivkumar Chiruvolu, Pravin K. Narwankar
Life of this patent
Estimating the term…
Abstract
A pharmaceutical composition containing a metal oxide coated particle comprising 1) an amorphous solid dispersion (ASD) core containing an active pharmaceutical ingredient (API) and a polymer; and 2) a metal oxide coating, and the method of making said metal oxide coated particle by atomic layer deposition (ALD). The metal oxide coated particle is useful because it prevents the ASD from crystallization and helps maintain the ASD in an amorphous form.
Claims16
Individual coated nanoparticles or microparticles, comprising:
- (a) nanoparticles or microparticles comprising an amorphous solid dispersion (ASD) of an active pharmaceutical ingredient (API) and a polymer;
- and
- (b) a coating layer comprising an inorganic oxide selected from the group consisting of aluminum oxide, zinc oxide, silicon oxide and titanium oxide enclosing the individual nanoparticles or microparticles, wherein the nanoparticles or microparticles comprise 50%-70% wt/wt API, wherein the polymer is selected from the group consisting of HPMCAS, PVPVA and PVP, and the coating layer allows the ASD to remain amorphous for at least one month longer, as compared to an otherwise identical ASD without the coating layer, when stored at 40° C. and 75% humidity.
Dependencies are inferred from the claim text.