Devices, systems and methods for treating and preventing venous insufficiency, thrombosis, orthostatic intolerance, and impaired lymphatic drainage

A method of treating or preventing venous deficiency insufficiency, thrombus development, or lymphedema comprising:

• applying a wearable device to a limb of a user, wherein the wearable device comprises:
• a sleeve wearable on a limb of the user;
• an upper bracket and a lower bracket releasably couplable to the limb;
• an actuator coupled to one of the upper or lower brackets;
• a shaft coupled to the actuator and the other of the upper or lower brackets;
• at least three cams fixedly coupled to, and longitudinally spaced along, the shaft, each cam having a nose with a nose height measured from the shaft, a first nose height of a first cam being greater than a second nose height of a second cam, the nose of adjacent cams having different angular positions with respect to the shaft;
• and
• a respective plurality of flexible elements each coupled to one of the plurality of cams and to the sleeve, wherein rotational motion of the actuator about an axis of rotation causes the plurality of cams, via the respective plurality of flexible elements, to induce a peristaltic first pressure wave in the limb.