Mid-infrared laser-activated tissue sealing using biomaterials
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsKaushal Rege, Ridha Inam, Yu Yao
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Abstract
A method of closing an opening in a tissue comprises providing a light absorbing material, introducing the light absorbing material into a tissue opening, and irradiating the light absorbing material with at least one light source so as to increase a temperature of the light absorbing material, causing the tissue edges of the tissue opening adhere to the light absorbing material and/or to each other. A kit comprising a light absorbing material and a light emitting device is also described.
Claims12
A method of closing an opening in a tissue comprising:
- providing a light absorbing material;
- wherein the light absorbing material is in the form of a liquid, a gel, a hydrogel, a paste, or a film;
- wherein the light absorbing material comprises a light absorbing polymer;
- wherein the light absorbing material comprises chitosan-glutaraldehyde, silk-glycerol, alginate-glycerol, or cellulose-glycerol;
- wherein the light absorbing material is devoid of gold particles, nanoparticles, chromophores, and light absorbing dyes;
- forming the opening in the tissue;
- introducing the light absorbing material directly into the opening in the tissue;
- irradiating the light absorbing material with at least one light source so as to increase a temperature of the light absorbing material, causing edges of the opening in the tissue to adhere to the light absorbing material and/or to each other;
- modulating the power of the light source to modulate the temperature increase from the light;
- and
- approximating the edges before, during, or after irradiating the light absorbing material;
- wherein the tissue is a single tissue;
- wherein the at least one light source comprises a mid-infrared laser light;
- and
- wherein the mid-infrared laser light has a wavelength between 2 microns and 10 microns.
A method of closing an opening in a tissue comprising:
- providing a light absorbing material;
- wherein the light absorbing material is in the form of a liquid, a gel, a hydrogel, a paste, or a film;
- wherein the light absorbing material comprises a light absorbing polymer;
- wherein the light absorbing material is devoid of gold particles, nanoparticles, chromophores, and light absorbing dyes;
- forming the opening in the tissue;
- introducing the light absorbing material directly into the opening in the tissue;
- irradiating the light absorbing material with at least one light source so as to increase a temperature of the light absorbing material, causing edges of the opening in the tissue to adhere to the light absorbing material and/or to each other;
- modulating the power of the light source to modulate the temperature increase from the light;
- and
- approximating the edges before, during, or after irradiating the light absorbing material;
- wherein the tissue is a single tissue;
- wherein the at least one light source comprises a mid-infrared laser light;
- wherein the mid-infrared laser light has a wavelength between 5 microns and 7 microns;
- wherein the light absorbing material comprises chitosan-glutaraldehyde, silk-glycerol, alginate-glycerol, or cellulose-glycerol;
- and
- wherein the light absorbing material comprises a photoinitiator.
Dependencies are inferred from the claim text.