On-body microsensor for biomonitoring

A wearable sensor for sensing analytes, the wearable sensor comprising:

• an analyte microsensor including a plurality of microneedles configured to detect at least one analyte in interstitial fluid in skin of a user, wherein at least one individual microneedle in the plurality of microneedles includes:
• a distal region;
• an active region isolated to the distal region, the active region including a sensing material operable to generate analyte signals upon detection of the at least one analyte and a conductive material isolated to the distal region;
• a base region;
• and
• a needle body with an insulating material extending between the base region and the distal region to electrically insulate the needle body of the at least one individual microneedle;
• an electronics module electrically coupled to the base region and programmed to receive output from the analyte microsensor and to determine analyte information about the at least one analyte based on the received output.