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US 12,642,449 B2Granted
Device and associated methods for simultaneous measurement of pulmonary ventilation and metabolic rate
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsRalph Fregosi, Christina Hoyer-Kimura
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Abstract
Various examples of a device for simultaneous measurement of pulmonary ventilation and metabolic rate are disclosed including a dual chamber configuration providing values for pulmonary ventilation and metabolic rate that compare favorably with the gold standard approaches.
Claims20
A system for simultaneous measurement of pulmonary ventilation and metabolic rate, comprising:
- a dual-chamber plethysmograph device including:
- a body defining a dual chamber configuration, including:
- a first chamber configured to receive a body of a test subject with a head of the test subject extending outside the first chamber, and
- a second chamber defining a size greater than the first chamber and surrounding at least a portion of the first chamber, the second chamber including gas outflow ports,
- a pneumotach fluidly coupled to the first chamber that generates an airflow signal indicative of pulmonary ventilation of the test subject;
- and
- a gas analyzer pump including O2 and CO2 sensors fluidly coupled to at least one of the gas outflow ports of the second chamber and configured to pull air through the dual-chamber plethysmograph and detect a rate of flow and concentrations of O2 and CO2 gas exiting the second chamber to measure a metabolic rate of the test subject.
4 more elements
A device for simultaneous and improved measurement of pulmonary ventilation and metabolic rate, comprising:
- a body defining a dual chamber configuration, including:
- a first chamber configured for a head-out plethysmograph, and
- a second chamber defining a size greater than the first chamber, the first chamber being disposed within the second chamber along a channel of the second chamber,
- the second chamber including
- at least one gas inflow port and at least one gas outflow port configured to permit a bias flow of gas through the second chamber,
- a gas analyzer fluidly coupled to the at least one gas outflow port of the second chamber, the gas analyzer including O2 and CO2 sensors that determine a metabolic rate of a test subject from gas exiting the second chamber, and
- at least one sensor associated with the first chamber and configured to generate a signal indicative of pulmonary ventilation of the test subject while the metabolic rate is determined from the gas analyzer.
4 more elements
A method for improved measurement of pulmonary ventilation and metabolic rate, comprising:
- positioning a test subject in a first chamber configured for a head-out plethysmograph so that a head of the test subject extends outside the first chamber;
- positioning the first chamber within a channel defined by a second chamber to define a dual chamber configuration with the second chamber surrounding at least a portion of the first chamber;
- flowing a bias gas through the second chamber between at least one gas inflow port and at least one gas outflow port of the second chamber;
- measuring a respiratory signal associated with the first chamber to obtain a pulmonary ventilation parameter of the test subject;
- and
- measuring O2 and CO2 concentrations of gas exiting the second chamber at the at least one gas outflow port with a gas analyzer and determining a metabolic rate of the test subject from the measured O2 and CO2 concentrations while the pulmonary ventilation parameter is measured.
3 more elements
Dependencies are inferred from the claim text.