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US 12,642,433 B2Granted
Quantitative measurement of the perivascular space for CNS and brain disorders
AssigneeNortheastern University
InventorsCraig Ferris, Ju Qiao, Praveen Kulkarni, Codi Gharagouzloo
Life of this patent
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Abstract
Disclosed are methods for quantification of a perivascular space in a subject's central nervous system. The methods include administering contrast agent into cerebrospinal fluid of the subject; performing quantitative ultra-short time-to-echo contrast-enhanced magnetic resonance imaging (QUTE-CE MRI) on a region of interest of the subject's brain; and determining presence of the contrast agent in the perivascular space within the region of interest.
Claims32
A method for evaluation of a perivascular space in a subject, the method comprising:
- determining at least one kinetic value of flow of perivascular space in a region of interest, the determining comprising:
- analyzing magnetic resonance imaging (MRI) data of the region of interest, the MRI data of the region of interest comprising first MRI data captured at a first time point and second MRI data captured at a second time point, one or more of the first time point or the second time point being after (a) a paramagnetic or superparamagnetic blood pool contrast agent was introduced into cerebrospinal fluid of the region of interest of the subject and (b) an occurrence of at least partial mixing of the cerebrospinal fluid with interstitial fluid, the analyzing the MRI data comprising identifying a first signal intensity for the first time point and a second signal intensity for the second time point, wherein each of the first signal intensity and the second signal intensity is obtained via an MRI device configured with a repetition time (TR) less than 10 ms and a time to echo (TE) less than 300 μs;
- calculating a longitudinal rate of a change in signal intensity in the region of interest, the longitudinal rate of change in signal intensity comprising a difference in signal intensity obtained from the paramagnetic or superparamagnetic blood pool contrast agent in at least a perivascular space of the region of interest based on a spatial volume of each of the first signal intensity and the second signal intensity;
- and
- evaluating the longitudinal rate of change in signal intensity to determine the at least one kinetic value of flow of the perivascular space within the region of interest.
2 more elements
A computing system comprising:
- one or more processors;
- and
- storage encoded with instructions that, when executed by the one or more processors, cause the one or more processors to perform a method comprising:
- determining at least one kinetic value of flow of tissue adjacent to vascular tissue in a region of interest of a subject, the determining comprising:
- analyzing magnetic resonance imaging (MRI) data of the region of interest, the MRI data of the region of interest comprising first MRI data captured at a first time point and second MRI data captured at a second time point, one or more of the first time point or the second time point being after (a) a paramagnetic or superparamagnetic blood pool contrast agent was introduced into cerebrospinal fluid of the region of interest of the subject and (b) an occurrence of at least partial mixing of the cerebrospinal fluid with interstitial fluid, the analyzing the MRI data comprising identifying a first signal intensity for the first time point and a second signal intensity for the second time point, wherein each of the first signal intensity and the second signal intensity is obtained via an MRI device configured with a repetition time (TR) less than 10 ms and a time to echo (TE) less than 300 μs;
- calculating a longitudinal rate of a change in signal intensity in the region of interest, the longitudinal rate of change in signal intensity comprising a difference in signal intensity obtained from the paramagnetic or superparamagnetic blood pool contrast agent in at least the tissue adjacent to the vascular tissue of the region of interest based on a spatial volume of each of the first signal intensity and the second signal intensity;
- and
- evaluating the longitudinal rate of change in signal intensity to determine the at least one kinetic value of flow of the tissue adjacent to the vascular tissue within the region of interest.
5 more elements
At least one non-transitory computer-readable storage medium having encoded thereon instructions that, when executed by at least one processor, cause the at least one processor to carry out a method comprising:
- determining at least one kinetic value of flow of perivascular space in a region of interest of a subject, the determining comprising:
- analyzing magnetic resonance imaging (MRI) data of the region of interest, the MRI data of the region of interest comprising first MRI data captured at a first time point and second MRI data captured at a second time point, one or more of the first time point or the second time point being after (a) a paramagnetic or superparamagnetic blood pool contrast agent was introduced into cerebrospinal fluid of the region of interest of the subject and (b) an occurrence of at least partial mixing of the cerebrospinal fluid with interstitial fluid, the analyzing the MRI data comprising identifying a first signal intensity for the first time point and a second signal intensity for the second time point, wherein each of the first signal intensity and the second signal intensity is obtained via an MRI device configured with a repetition time (TR) less than 10 ms and a time to echo (TE) less than 300 μs;
- calculating a longitudinal rate of a change in signal intensity in the region of interest, the longitudinal rate of change in signal intensity comprising a difference in signal intensity obtained from the paramagnetic or superparamagnetic blood pool contrast agent in at least a perivascular space of the region of interest based on a spatial volume of each of the first signal intensity and the second signal intensity;
- and
- evaluating the longitudinal rate of change in signal intensity to determine the at least one kinetic value of flow of the perivascular space within the region of interest.
2 more elements
Dependencies are inferred from the claim text.