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US 12,642,256 B2Granted
Hemophilia B rat model
AssigneeToolgen Incorporated
InventorsJae Young Lee, Hee Sook Bae, Hye Jung Shin, Dong Woo Song, Un Gi Kim, Kyu Jun Lee
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Abstract
The present invention relates to a hemophilia B rat and a method of producing the hemophilia B rat. More particularly, the present invention relates to a hemophilia B rat having F9 factor knocked-down or knocked-out and a method of producing the hemophilia B rat.
Claims1
A hemophilia B rat model comprising artificial modification in F9 gene, wherein the artificial modification in F9 gene comprises one or more modifications of:
- a deletion of a whole or partial sequence of F9 gene;
- an insertion in a whole or partial sequence of F9 gene;
- an insertion and deletion of a whole or partial sequence of F9 gene;
- and
- an inversion in F9 gene,
- wherein the partial sequence of F9 gene is a 1 bp to 100 bp nucleotides,
- wherein the hemophilia B rat comprises, thereby the artificial modification in F9 gene, one or more of:
- a reduced expression level of F9 factor;
- an inhibited expression of F9 factor;
- a hypofunction of F9 factor;
- and
- a lost function of F9 factor, and
- wherein the hemophilia B rat exhibits one or more phenomena of:
- a spontaneous bleeding in tissues;
- an inflammation in tissues caused by spontaneous bleeding;
- and
- a swelling in tissues caused by spontaneous bleeding,
- wherein the artificial modification in F9 gene occurs in the second exon region of F9 gene.
15 more elements
Dependencies are inferred from the claim text.