Nanopore assemblies and uses thereof
AssigneeOxford Nanopore Technologies PLC
InventorsFarzin Haque, Shaoying Wang
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Abstract
The disclosure provides a nanopore system assembled with non-membrane proteins for detecting analytes. Also disclosed are the methods, kits, and detection devices employing the disclosed nanopore system. The nanopore system has a wide variety of applications, including single molecule detection, DNA/RNA/peptide sequencing, sensing of chemicals, biological reagents, and polymers, and disease diagnosis.
Claims19
A nanopore assembly comprising a channel formed of a plurality of subunits, wherein each subunit comprises a polypeptide having the amino acid sequence of SEQ ID NO:3 that comprises at least one substitution at one or more positions independently selected from K134I, D138L, D139L, D158L, E163V, E309V, D311V, K321V, K356A, K358A, D377A, D381V, N388L, R524I, R539A, and E595V.
Dependencies are inferred from the claim text.