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US 12,638,451 B2Granted
Genetic amplified tumor homing nanoparticles and compositions and methods thereof
AssigneeUniversity of Massachusetts
InventorGang Han
Life of this patent
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Abstract
The invention provides novel genetic probes and bioactive agents and compositions and methods of use thereof in diagnostic and therapeutic applications.
Claims4
A genetic probe for specific upregulation of transferrin receptor (TfR) expression level in an infected prostate cancer (PCa) cell without upregulating TfR expression level in a nonmalignant prostate cell, wherein the genetic probe is an adenovirus vector represented by
- Ad.PDD3-TfR-WPRE-PCMV-Luc,
- wherein PDD3 represents the promoter of differential display code 3 (DD3) gene, TfR represents TfR gene, and WPRE represents a woodchuck hepatitis virus post-transcriptional regulatory element sequence.
Dependencies are inferred from the claim text.