Multi-antigen diagnostic for detecting lyme disease
AssigneesFocus on Lyme Foundation, The Administrators of the Tulane Educational Fund
InventorsMonica Embers, Tammy Crawford, Holly Ahern
Life of this patent
Estimating the term…
Abstract
This application relates to methods of diagnosing Lyme disease. In some embodiments, the methods include detecting levels of at least one antigen in a sample. In some embodiments, the methods include a combination of detecting levels of at least one antigen in a sample and classifying samples using one or more decision trees.
Claims6
A set of reagents to measure the levels of biomarkers in a specimen, wherein the biomarkers are a binding molecules each binding molecule bound to an imaging agent, each binding molecule capable of binding one antigen in a panel of antigens, the panel selected from the group consisting of the following panels and each panel consisting of the specified antigens or measurable fragments thereof:
- (a) outer surface protein C2 (OspC2), and an 26-amino acid peptide within the VIsE protein (C6);
- (b) C6, glycerophosphodiester phosphodiesterase protein (GlpQ), protein p35 (p35), porin protein p66 or the protein p66 (p66), outer surface protein C (OspC) decorin-binding protein A (DbpA), periplasmic oligopeptide binding protein (OppA2), protein exported repeated protein Q (ErpQ), outer surface protein E (OspE), OspC2;
- (c) C6, p35, p66, OspC, DbpA, OppA2, ErpQ, OspE, OspC2;
- (d) OspC2, OspC, C6, and p35;
- (e) OspC2, OspC, C6, and p66;
- (f) OspC2, OspC, C6, and DbpA;
- (g) OspC2, OspC, C6, and OppA2;
- (h) OspC2, OspC, Co, and ErpQ;
- and
- (i) OspC2, OspC, C6, and OspE.
A set of antigens fixed to a plurality of beads to measure the levels of biomarkers in a specimen, wherein the biomarkers are antibodies each antibody bound to an imaging agent, each antibody capable of binding one antigen in a panel of antigens selected from the group consisting of the following panels and each panel consisting of the specified antigens or measurable fragments thereof:
- (a) OspC2, and C6;
- (b) C6, GlpQ, p35, p66, OspC, DbpA, OppA2, ErpQ, OspE, OspC2;
- (c) C6, p35, p66, OspC, DbpA, OppA2, ErpQ, OspE, OspC2;
- (d) OspC2, OspC, Co, and p35;
- (e) OspC2, OspC, C6, and p66;
- (f) OspC2, OspC, C6, and DbpA;
- (g) OspC2, OspC, C6, and OppA2;
- (h) OspC2, OspC, C6, and ErpQ;
- and
- (i) OspC2, OspC, C6, and OspE.
Dependencies are inferred from the claim text.