Interface between liquid chromatography, ionization device, and mass spectrometer, and sample analysis method using the same

An interface between a liquid chromatography (LC), an ionization device, and a mass spectrometer (MS), wherein a sample containing a target eluted from the liquid chromatography is ionized by the ionization device and the ionized sample is introduced into the mass spectrometer, wherein the interface comprises:

• a droplet sprayer;
• an evaporator having a heatable block, wherein the heatable block has one or more openings;
• and
• an introduction tube,
• wherein the droplet sprayer is for converting the sample containing the target eluted from the liquid chromatography into sample droplets and for spraying the sample droplets into the evaporator,
• wherein the evaporator is for evaporating a solvent of the sample droplets to generate a gaseous target by passing the sample droplets through the one or more openings,
• wherein the introduction tube is for receiving the gaseous target from the evaporator and for introducing an ionized gaseous target into the mass spectrometer,
• wherein the ionization device ionizes the gaseous target passing through the introduction tube by irradiating the gaseous target in the introduction tube with a beam to form the ionized gaseous target, and
• wherein a first end of each of the one or more openings facing the droplet sprayer has an inclined surface, and wherein a diameter of the first end decreases along the inclined surface in a direction of flow of the sample droplets.